|
Prof
Samuel Sai-ming SUN
(Reseach Professor of Biology)
(Academician, The Chinese Academy of Engineering
and
International Eurasian Academy of Sciences)
Address: |
Room
G88, Science Centre, CUHK (Off); |
| |
Room G90-G91,
Science Centre, CUHK (Lab) |
| Phone: |
(852)
2609-6286 (Off); |
| |
(852)
2609-6113 (Lab) |
| Fax: |
(852)
2603-6382, (852) 2603-5646 |
| E-mail: |
ssun@cuhk.edu.hk |
| |
| |
| Education |
| 1974 |
PhD
(Botany/Horticulture), University of Wisconsin, Madison, USA |
| 1970 |
MSc
(Botany), University of Hong Kong, Hong Kong |
| 1968 |
BSc
Special Honors (Botany), University of Hong Kong, Hong Kong |
| 1966 |
BSc
cum laude (Biology), The Chinese University of Hong Kong,
Hong Kong |
|
Position |
| 2008-present |
Research Professor
of Biology (Dept of Biology, The Chinese University of Hong
Kong, Hong Kong) |
| 1995-2008 |
Professor
of Biology (Dept of Biology, The Chinese University of Hong
Kong, Hong Kong) |
| 1996-2004 |
Chairman
(Dept of Biology, The Chinese University of Hong Kong, Hong
Kong) |
| 1991-1995 |
Professor
(Dept of Plant Molecular Physiology, University of Hawaii,
Manoa, USA) |
| 1988-1990 |
Associate
Professor (Dept of Plant Molecular Physiology, University
of Hawaii, Manoa, USA) |
| 1986-1987 |
Director
(Molecular Biology, Plant Cell Research Institute, CA, USA) |
| 1981-1985 |
Senior
& Principal Scientist (ARCO Plant Cell Research Institute,
CA, USA) |
| 1979-1980 |
Assistant
Scientist (University of Wisconsin, Madison, USA) |
| 1975-1979 |
Postdoctural
Associate (University of Wisconsin, Madison, USA) |
| 1968-1970 |
Senior Demonstrator (Botany Department, University of Hong
Kong, Hong Kong) |
| 1966-1967 |
High School Teacher (Kowloon Tong School, Hong Kong) |
| Concurrent
Position |
Master, S.H. Ho College ,
CUHK |
Director, State Key Laboratory of Agrobiotechnology,
CUHK |
Director,
Institute of Plant Molecular Biology and Agricultural Biotechnology,
CUHK |
Coordinator, UGC (HKSAR) - Area of Excellence on Plant and Agricultural Biotechnology |
Member, Research Grants Council, HKSAR |
Academic
Council Member, National Laboratory of Agricultural Biotechnology,
China Agricultural University, China |
Board
Member, Germplasm Improvement Program, National Engineering
Research Center for Vegetables, China |
Coordinator,
Joint Laboratory for Plant Molecular Biology and Biotechnology,
Peking University and the Chinese University of Hong Kong |
|
Professor
/ Adjunct / Visiting Professor (China Agricultural University,
The University of Science and Technology in China, Nankai
University, Tsinghua University, Wuhan University, Zhejiang
University, Huazhong Agricultural University, Northwest Agricultural
University, Chinese Agricultural Academy of Sciences, Beijing
Vegetable Research Center, and Zhanjiang Oceanic University,
China) |
| Professional
Activities and Recognition |
Awards: |
Science and Technology Award, Zhejiang Province (2007) |
Leader of the Year (Education/Research), Hong Kong (2005) |
Greatwall
Friendship Award, The People's Government of Beijing Municipality,
China (2000) |
| Friendship
Medal, The State Government, China (1996) |
ARCO
Distinguished Research Award (1984) |
Membership in the following Professional
Organizations:
|
American
Society of Plant Biologists |
Society
of Chinese Bioscientists in America |
American
Association for the Advancement of Sciences |
Hong
Kong Society of Biochemistry and Molecular Biology |
|
Research Interests |
| 1. |
Plant
molecular biology and biotechnology |
| 2. |
Plant
gene isolation, characterization, transfer, expression, and
regulation |
| 3. |
Plant
bioreactors |
| 4. |
Rice
quality improvement and functional genomics |
|
Representative Publications |
| 1. |
Sun, S.S.M. (2008) Review article: Application of agricultural biotechnology to improve food nutrition and healthcare products. Asia Pac. J. Clin. Nutri. 17(S), 87-90.
|
| 2. |
Sun, S. S.M. (2008) Transgenics for new plant products, applicable to tropical crops. In: Genomics of Tropical Plants. Moore & Ming eds. Springer Publication, pp. 63-81.
|
| 3. |
Xiao, G.Y., Yuan, L.P. and Sun, S.S.M. (2007) Strategy and utilization of herbicide resistance gene in two-line hybrid rice. Molecular Breeding 20:287-292. |
| 4. |
Duan,
M.J. and Sun,
S.S.M.
(2005)
Profiling the expression of genes controlling rice grain quality.
Plant Mol. Biol. 59:165-178. |
| 5. |
Sun,
S.S.M.
and Liu, Q.Q. (2003) Transgenic approaches to improve the
nutritional quality of plant proteins. In Vitro Cell.
Devel. Biol.-Plant (MiniReview) 40:155-162. |
| 6. |
Sun,
S.S.M.
(2002) The future of agricultural biotechnology in Asia (Editorial).
Research Report. 1:2 |
|
7. |
Jiang,
L.W. and Sun, S.S.M. (2002) Membrane
anchors for vacuolar targeting: application in plant bioreactors.
Trends in Biotech. 20:99-102. |
|
8. |
Gao,
Y.F., Jing, Y.X., Shen, S.H. and Sun,
S.S.M. (2001) Transfer of lysine-rich protein gene
into rice and production of fertile transgenic plants (in
English). Acta Botanica Sinica 43:506-511. |
|
9. |
Sun,
S.S.M.,
Wang, M.L., Tu, H.M., Zuo, W.N., Xiong, L.W., Cheng, M.K.S.
and Leung, J.C.W. (2000) Transgenic approach to improve crop
quality. In: Green genes for 21st century, Z.P. Lin, ed.,
Science Press, Beijing, pp. 22-43 ( In English). |
|
10. |
Sun,
S.S.M.
(1999) Methionine enhancement in plants. In: Plant Amino Acids:
Biochemistry and Biotechnology, B.K. Singh, Ed., Marcel Dekker,
Inc., N.Y., pp. 509-522. |
|
11. |
Tu,
H.M., Godfrey, L.W. and Sun, S.S.M.
(1998) Expression of the Brazil nut methionine-rich
protein and mutants with increased methionine in transgenic
potato. Plant Mol. Biol. 37:829-838. |
|
12. |
Sun,
S.S.M.,
Zuo, W.N., Tu, H.M. & Xiong, L.W. (1996) Plant proteins
- Engineering for improved quality. In: Engineering Plants
for Commercial Products and applications. Ann. New York
Acad. Sci. 792:37-42. |
| 13. |
Zuo,
Wei-neng and Sun, S.S.M. (1996)
Purification and Characterization of the methionine-rich 2S
seed proteins from the Brazil nut family (Lecythidaceae).
J. Agri. Food Chem. 44:1206-1210. |
|
14. |
Sun,
S.S.M. (1994)
Methods in Plant Molecular Biology and Agricultural Biotechnology
- A Laboratory Training Manual. Asian Vegetable Research and
Development Center. Shanhua, Tainan, Taiwan (ROC). |
|
15. |
Kim,
J.W., Sun, S.S.M. and German,
T. (1993) Disease resistance in tobacco and tomato plants
transformed with the tomato spotted wilt virus nucleocapsid
gene. Plant Disease 78:615-621. |
|
16. |
Sun,
S.S.M. and
Larkins, B.A. (1992) Transgenic plants for improving seed
storage proteins. In: Transgenic Plants, vol. 1., Eds. S.D.
Kung and R. Wu. Academic Press, pp. 317-372. |
|
17. |
Altenbach,
S.B., Pearson, K.W., Meeker, Staracy, L. and
Sun, S.S.M. (1989) Enhancement of the methionine content
of seed protein by the expression of a chimeric gene encoding
a methionine-rich protein in transgenic plants. Plant
Mol. Biol. 13:513-522. |
|
18. |
Osborn,
T.C., Alexander, D.C., Sun, S.S.M.,
Cardona, C. and Bliss, F.A. (1988) Insecticidal activity and
lectin homology of arcelin seed protein. Science
240:207-212. |
|
19. |
Altenbach,
S.B., Pearson, K.W., Leung, F.W. and Sun,
S.S.M. (1987) Cloning and sequence analysis of a cDNA
encoding a Brazil nut protein exceptionally rich in methionine.
Plant Mol. Biol. 8:239-250 |
| 20. |
Slightom,
J.S., Sun, S.S.M. and Hall, T.C.
(1983) Complete nucleotide sequence of a French bean storage
protein gene: Phaseolin. Proc. Natl. Acad. Sci. USA
80:1897-1901. |
| 21. |
Sun,
S.S.M.,
Slightom, J.S. and Hall, T.C. (1981) Intervening sequence
in a plant gene: comparison of the partial sequence of cDNA
and genomic DNA of French bean phaseolin. Nature
289:37-41. |
| Patents |
| 1. |
Sulfur-rich
protein from Bertholletia excelsa HBK (European patent
#EP0295959, 1988) |
| 2. |
Arcelin
seed storage proteins from Phaseolus vulgaris (US patent
#5270200, 1993) |
| 3. |
Recombinant
sweet protein mabinlin (US patent #6051758, 2000) |
| 4. |
Lysine
rich protein from winged bean (US patent #6184437, 2001) |
|
5.
|
Transgenic plant product comprising human granulocyte colony-stimulating factor and method for preparing the same (HK patent #1071908, 2007) and (China patent #200410037474.x, 2007)
|
| 6. |
Epitope
identification and modification for reduced allergenic activity
in proteins targeted for transgenic expression (US patent #7399597, 2008) |
| 7. |
Isolated proteins from a traditional Chinese medicine Yuzhu and use thereof (US patent #7378513, 2008) |
| 8. |
Methods
to produce desired proteins in plants (US patent #7425667, 2008) |
| Research
Grants ( CUHK 1996-present) |
| University
Grants Committee (UGC) Area of Excellence (AoE) Scheme |
| 2007-2010 |
AoE on Centre for Plant and Agricultural Biotechnology - HK$25.0M (Centre Coordinator) |
| 2000-2006 |
AoE on
Plant and Fungal Biotechnology - HK$38.8M (Center Director
and PI) |
| |
| Bill
and Melinda Gates Foundation: Grand Challenges in Global Health
Grants |
| 2005-2010 |
Engineering
rice for high beta-carotene, vitamin E, protein and enhanced
iron and zinc bioavailability - US$0.9M (Consortium member;
PI, Dr. P Beyer) |
Research Grants Council (RGC) Earmarked
Grants |
| 2005-2008 |
The
biology of vacuolar sorting receptor proteins and their applications
in plant bioreactors - HK$1.4M (PI; Co-PI, Dr. LW Jiang) |
|
2003-2005 |
Cloning of cDNA encoding a novel potent antiviral protein
isolated from the chinese medicinal herb and its transqenic
expression in plants - HK$0.5M (Co-PI; PI, Dr VEC Ooi) |
| 2001-2004 |
Sorting of proteins to the protein storage vaxuole in plant
cells - HK $1.1M (Co-PI; PI, Dr LW Jiang) |
| 2000-2002 |
Sink-source
relationship during seed development in Arabidopsis thaliana
- Molecular regulation of aspartate faminly amino acids - HK
$1.0M (Co-PI; PI, Dr HM Lam) |
| 1998-2001 |
Engineering
the Brazil nut Met-rich protein for reduced allergenic Activity
- HK$1.2M (PI; Co-PI, Dr CWK Lam) |
| 1997-1999 |
Genetic
engineering of sweet protein mabinlin for increased stability
- HK$0.6M (PI; Co-PI, Dr YS Wong) |
| 1997-1999 |
Characterization
and expression of ribosomal inactivating proteins in plants
and mushrooms - HK $0.7 (Co-PI; PI, Dr VEC Ooi; Co-PI,
Dr TB Ng) |
| 1996-1998 |
Genetic
engineering of rapeseed for enhanced nutritional quality - HK
$0.7M (PI) |
Research Grants Council (RGC) Central
Allocation Fund |
| 1999 |
Automated
microbial identification system - HK $2.9M (Co-ordinator;
PIs, Dr PK Wong, Dr HS Kwan and BU & PolyU as Co-PIs) |
Industrial Support Fund |
| 1998-2001 |
Production
of high value pharmaceutical proteins in transgenic seeds
- HK$5.2M (PI; Co-PI, Dr MC Fung and Dr HM Lam) |
Hong Kong University Grant Council (UGC) Seed Grant |
| 1998-1999 |
Area
of Excellence in Plant and Fungal Biotechnology - HK $1.5M
(Co-ordinator; 10 other biology faculty team members as Co-PIs) |
SHARF Fund |
| 2001-2004 |
Genomic
and functional genomic studies of stress tolerance in rice
- HK $2.0M & RMB 5.0M (PI; Co-PI, Dr HM Lam
(CUHK) and PI, Dr ZH He & Dr HX Lin, and Co-PIs Dr B Han
& Dr D Luo (SIPP, China) |
Direct Grants of the Research Committee,
CUHK |
| 1996-1997 |
Development
of a plant bioreactor for the production of high value proteins
- HK$0.1M |
CUHK Special Fund |
| 1999-2000 |
CUHK-Peking
Univ Joint Lab of Plant Molecular Biology and Biotech - HK $0.5M
(Co-ordinator) |
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