|
Prof
Diane Dianjing GUO
|
Address:
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Room G81, Science Centre, CUHK (Off); |
| |
Room G94,
Science Centre, CUHK (Lab) |
| Phone: |
(852)
2609-6298 (Off) |
| Fax: |
(852)
2603-5646, (852) 2603-5745 |
| E-mail: |
djguo@cuhk.edu.hk |
| Education |
| 1998 |
PhD (Plant Molecular Biology),
Institute of Genetics, Chinese Academy of Sciences |
| 1994 |
MSc (Plant
Biotechnology), Northeast Agricultural University, China |
| 1991 |
BSc (Bioengineering), Northeast Agricultural University, China |
| Position |
| 2005- |
Assistant
Professor (Department of Biology, The Chinese University of
Hong Kong, Hong Kong)
|
| 2002-2005 |
Senior
Research Associate (Virginia Bioinformatics Institute, Virginia
Tech, USA)
|
| 2001-2002 |
Postdoctoral
fellow (Virginia Bioinformatics Institute, Virginia Polytech.
Institute & State University, USA) |
| 1998-2001 |
Postdoctoral
fellow (Plant Biology Division, Samuel Roberts Noble Foundation,
USA) |
| |
|
| Concurrent
Position |
| 2006-present |
Adjunct
Associate Professor, Harbin Institute of Technology, China
|
| 2004-present |
Adjunct
Professor, School of Life Sciences, Northeast Agricultural
University, China
|
| 2000-present |
Adjunct
Associate Professor, Institute of Genetics and Developmental
Biology, CAS, China
|
Professional
Activities
Membership in the following Professional
Organizations:
Hong Kong Society of Mass Spectrometry (Counsel member)
The American Society for Plant Biologists
The International Society for Computational Biology
Research
Interests
1. Secondary metabolism of medicinal plants
2. Bioinformatics and systems biology
3. Plant biotic and abiotic stress
| Representative
Publications |
| 1. |
Wu, W., Zhang, Q., Liu, Y., Wang, W., Qi, Y., Ren, D., Sun, S.S.M. and Guo, D. (2008) Methyl Jasmonate induces differential metabolic responses in different A. annua chemotypes. Journal of Experimental Botany. (submitted) |
| 2. |
Wu, W., Zhang, Q., Zhu, Y., Lam, H., Cai, Z. and Guo, D. (2008) Comparative metabolic profiling reveals secondary metabolites associated with soybean salt tolerance. BMC Plant Biology. (submitted) |
| 3. |
Xie, Y., Li, W., Guo, D., Dong, J., Zhang, Q., Ren, D., Peng, M. and Xia, Y. (2008) Arabidopsis SIGMA FACTOR-BINDING PROTEIN 1 (SIB1) functions in disease resistance as a positive regulator of the redox-mediated defense response. Plant Physiology. (submitted) |
| 4. |
Zhang Q., Yu, P., Liu, Y., Sun, S.S.M. and Guo, D. (2008) A probabilistic graphical model for gene function and transcriptional network inference. Molecular Biosystems. (in revision)
|
| 5. |
Li, Y., Zhu, Y., Liu, Y., Shu, Y., Meng, F., Lu ,Y., Liu, B., Bai, X. and Guo, D. (2008) Genome wide identification of osmotic stress response gene in Arabidopsis thaliana. Genomics. (in press)
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| 6. |
Li, Y., Zhu, Y., Shu, Y., Liu, Y., Meng, F., Bai, X. and Guo, D. (2008) Cis-regulatory element based gene finding: an application in Arabidopsis. Genome Informatics. (in press)
|
| 7. |
Zhang, S., Ching, W., Tsing, N., Leung, H. and Guo, D. (2008) A multiple regression approach for building genetic networks. IEEE BMEI 2008 pp. 18-23.
|
| 8. |
Kota, P., Guo, D., Zubieta, C., Noel, J. and Dixon, R.A. (2004) O-Methylation of benzaldehyde derivatives by "lignin specific" caffeic acid 3-O-methyltransferase. Phytochemistry 65, 837-846.
|
| 9. |
Marira,
J., Ralph, J., Hatfield, R., Guo, D.,
Chen, F., and Dixon, R. (2003) Structural and compositional
modifications in lignin of transgenic alfalfa down-regulated
in caffeic acid 3-O-methyltransferase and caffeoyl coenzyme
A 3-O-methyltransferease. Phytochemistry 62: 53-65.
|
| 10. |
Li,
X., Brazhnik, O., Kamal, A., Guo, D.,
Lee, C., Hoops, S., and Mendes, P. (2002) Database and visualization
for metabolomics. Book chapter of Metabolite Profiling: Its
Role in Biomarker Discovery and Gene Function Analysis. pp.
293-309.
|
| 11. |
Guo,
D.
and Dixon, RA. (2002) Monolignol biosynthesis in microsomal
preparation from lignifying stems of alfalfa. Phytochemistry
61: 657-667.
|
| 12. |
Guo,
D.,
Chen, F., Inoue, K., and Dixon, R.A. (2001) Down-regulation
of caffeic acid 3-O-methyltransferase and caffeoyl CoA 3-O-methylytransferase
in transgenic alfalfa (Medicago sativa L.): Impacts
on lignin structure and implications for the biosynthesis
of G and S lignin. The Plant Cell 13: 73-88.
|
| 13. |
Guo,
D.,
Chen, F., Wheeler, J., Winder, J., Selman, S., Peterson, M.,
and Dixon, R.A. (2001) Improvement of in-rumen digestibility
of alfalfa forage by genetic manipulation of lignin O-methyltransferases.
Transgenic Research 10: 457-464.
|
| 14. |
Kota,
P., Chen, F., Guo, D., Blount,
J.W. and Dixon, R.A. (2001) Substrate preferences of lignin
O-methyltransferases in alfalfa (Medicago sativa L.)
suggest novel pathways to guaiacyl and syringyl units. The
Plant Journal 25: 1-11.
|
| 15. |
Dixon,
R.A., Chen, F., Guo, D., and
Kota, P. (2001) The biosynthesis of monolignols: a "metabolic
grid", or independent pathways to guaiacyl and syringyl units?
Phytochemistry 57: 1069-1084.
|
| 16. |
Dixon,
R.A., Chen, F., Guo, D., He,
X.Z., Liu, C.J., Noel, J.P., Parvathi, K., and Zubieta, C.
(2001) Properties and metabolic engineering of alfalfa O-methyltransferases
of phenylpropanoid biosynthesis. Recent Advances in Phytochemistry
35: 131-151.
|
| 17. |
Zhang,
X., Guo, D., Li, W., Zhang, L.,
and Sun, Y. (2000) Generation of transgenic tomato containing
NP-1 gene through Agrobacterium-mediated transformation and
in vitro, in vivo antibacterial activity against
Fusarium oxysporum. Chinese J. of High Technology
Letters 6(3).
|
| 18. |
Guo,
D.,
Fu, R., Li W, and Sun, Y. (1999) Rabbit Defensin (NP-1) gene
transformation of wheat and in vitro microbicidal activity
assay of transgenic plants. Chinese J. of High Technology
Letters 5(1).
|
| 19. |
Guo,
D.,
Li, W., and Sun, Y. (1999) Studies on regulation of gus
transient expression and rabbit defensin (NP-1) transformation
in wheat. ACTA Genetica Sinica 26(2).
|
| Research
Grants |
| Direct
Grants of the Research Committee, CUHK |
| 2005-2006 |
EST
database approach for gene discovery in Artemisia annua
glandular trichomes -$100,000 (PI)
|
National Science Foundation Committee of
China (NSFC) |
| 2006-2008 |
Plant
osmotic stress-response gene mining and functional analysis
- RMB $260,000 (PI)
|
Research Grants Council (RGC) Competitive Earmarked Research Grants (CERG) |
| 2007-2009 |
An integrated functional genomics approach towards understanding artemisinin metabolism - $1,052,500 (PI)
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Hong Kong Universities Grant Council (UGC) - Area of Excellence on Plant & Fungal Biotechnology Program |
| 2008-2010 |
Metabolomics and bioinformatics study of soybean and rice for crop quality improvement - $1,200,000 (co-PI)
|
CUHK Scheme D |
| 2008 |
Enhancing the capabilities and strengthening the research personnel of CUHK in Bioinformatics - $1,508,000 (co-I)
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