| |
| Prof
Wei Ge
Address: |
Room E109, Science Centre, CUHK (Off); |
| |
Room G93,
Science Centre, CUHK (Lab) |
| Phone: |
(852)
2609-6145 (Off); |
| |
(852)
2609-6121 (Lab) |
| Fax: |
(852)
2603-5646, (852) 2603-5745 |
| E-mail: |
weige@cuhk.edu.hk |
| Education |
| 1993 |
PhD
(Reproductive Physiology), University of Alberta, Canada |
| 1985 |
MSc (Genetics
and Developmental Biology), Academia Sinica, China |
| 1982 |
BSc (Experimental
Zoology), Nanjing University, China |
| Position |
| 2004-present |
Professor (Dept of Biology, The Chinese University of Hong Kong, Hong Kong) |
| 1999-2004 |
Associate
Professor (Dept of Biology, The Chinese University of Hong
Kong, Hong Kong) |
| 1995-1999 |
Assistant
Professor (Dept of Biology, The Chinese University of Hong
Kong, Hong Kong) |
| 1994-1995 |
NSERC
Postdoctoral Fellow (Dept of Developmental Biology, National
Institute for Basic Biology, Japan) |
| 1993 |
Postdoctoral
Fellow (Dept of Biological Sciences, University of Alberta,
Canada) |
| Research
Interest |
| 1.
Reproductive physiology and molecular endocrinology |
| 2.
Growth factors in the development and function of the brain-pituitary-gonad
(BPG) axis |
| 3.
Endocrine and paracrine regulation of ovarian functions |
| 4.
Molecular biology of gonadotropins and their receptors |
| Representative
Publications |
| 1. |
Ge,
W. (2005) Intrafollicular paracrine
communication in the zebrafish ovary: The state of the art
of an emerging model for the study of vertebrate folliculogenesis.
Molecular and Cellular Endocrinology 237:1-10. (Invited
At-the-Cutting-Edge review)
|
| 2. |
Kwok, H.-F., So, W.-K., Wang, Y. and
Ge, W.
(2005) Zebrafish gonadotropins and their receptors: I. Cloning
and characterization of zebrafish follicle-stimulating hormone
and luteinizing hormone receptors (Fshr and Lhr) - Evidence
for their distinct functions in follicle development. Biology
of Reproduction 72:1370-81.
|
| 3. |
So,
W.-K., Kwok, H.-F. and Ge, W.
(2005) Zebrafish gonadotropins and their receptors: II. Cloning
and characterization of zebrafish follicle-stimulating hormone
(FSH) and luteinizing hormone (LH) subunits - Their spatial-temporal
expression patterns and receptor specificity. Biology of
Reproduction 72:1382-96.
|
| 4. |
Ge,
W. (2005) Activin and its receptors in fish reproduction.
In: Melamed, P. and Sherwood, N. (eds) Hormones
and their receptors in fish reproduction. World Scientific
Publishing Co., Singapore, pp. 128-154. (invited book chapter)
|
| 5. |
Lau,
M.-T. and Ge, W. (2005) Cloning
of Smad2, Smad3, Smad4 and Smad7 from the goldfish pituitary
and evidence for their involvement in activin regulation of
goldfish FSH£] promoter activity. General and Comparative
Endocrinology. (in press).
|
| 6. |
Wang, Y. and Ge, W. (2004) Developmental profiles of activin £]A, £]B and follistatin expression in the zebrafish ovary - evidence for their differential roles during sexual maturation and ovulatory cycle. Biology of Reproduction 71: 2056-2064. |
| 7. |
Wang, Y. and Ge, W. (2004) Cloning of epidermal growth factor (EGF) and EGF receptor (EGFR) from the zebrafish ovary and its potential roles in the regulation of ovarian activin/follistatin system. Biology of Reproduction 71: 749-760. |
| 8. |
Yuen,
C.W. and Ge, W. (2004) Follistatin
suppresses FSH
but increases LH
expression in the goldfish-Evidence for an activin-mediated
autocrine/paracrine system in fish pituitary. General
and Comparative Endocrinology 135: 108-115. |
| 9. |
Wang,
Y., Wong, A.O.L. and Ge, W. (2003)
Cloning, regulation of mRNA expression and function of a new
isoform of pituitary adenylate cyclase-activating polypeptide
(PACAP) in the zebrafish ovary. Endocrinology 144:
4799-4810. |
| 10. |
Wang,
Y. and Ge, W. (2003) Spatial
expression patterns of activin and its signaling system in
the zebrafish ovarian follicle - evidence for paracrine action
of activin on the oocytes. Biology of Reproduction
69: 1998-2006. |
| 11. |
Wang,
Y. and Ge, W. (2003) Gonadotropin
regulation of follistatin expression in the cultured ovarian
follicle cells of zebrafish, Danio rerio. General
and Comparative Endocrinology 134: 308-315. |
| 12. |
Wang,
Y. and Ge, W. (2003) Involvement
of cyclic adenosine 3',5'-monophosphate in the differential
regulation of activin A
and B expression
by gonadotropin in the zebrafish ovarian follicle cells. Endocrinology
144: 491-499. |
| 13. |
Wang, Y. and Ge, W. (2002) Cloning
of zebrafish ovarian carbonyl reductase-like 20 -hydroxysteroid
dehydrogenase and characterization of its spatial and temporal
expression. General and Comparative Endocrinology
127:209-216. |
| 14. |
Pang,
Y.F. and Ge, W. (2002) Epidermal
growth factor (EGF) and transforming growth factor-
(TGF-) promote
zebrafish oocyte maturation in vitro: potential role of the
ovarian activin regulatory system. Endocrinology
143:47-54. |
| 15. |
Pang,
Y.F. and Ge, W. (2002) Gonadotropin
and activin enhance maturational competence of the oocytes
in the zebrafish, Danio rerio. Biology of Reproduction
66:259-265. |
| 16. |
Pang,
Y.F. and Ge, W. (2002) Gonadotropin
regulation of activin A
and activin type II receptor expression in the ovarian follicle
cells of the zebrafish, Danio rerio. Molecular
and Cellular Endocrinology 188:195-205. |
| 17. |
Ge,
W.
(2000) Roles of activin regulatory system in fish reproduction.
Canadian Journal of Physiology and Pharmacology 78:1077-1085. |
| 18. |
Pang,
Y.F. and Ge, W. (1999) Activin
stimulation of zebrafish oocyte maturation in vitro and its
potential role in mediating gonadotropin-induced oocyte maturation.
Biology of Reproduction 61:987-992. |
| 19. |
Yam,
K.M., Yu, K.L. and Ge, W. (1999)
Molecular cloning and characterization of goldfish activin
A subunit
cDNA. Molecular and Cellular Endocrinology 154:45-54. |
| Research
Grants |
| Research
Grants Council (RGC) Earmarked Grants |
| 2006-2008 |
Functional analysis of pituitary-gonadal
axis in the zebrafish ¡V Why do fish need two gonadotropins,
and what is the physiological relevance of FSH? - $1,397,914 |
| 2005-2007 |
Intrafollicular
communication in the zebrafish ovary ¡V roles of GDF-9 from
the oocyte in orchestrating follicle development - $1,321,920
|
| 2002-2004 |
Epidermal
growth factor (EGF) in the ovary of zebrafish - how is it
related to the ovarian activin system in controlling oocyte
development? - $876,000
|
| 2001-2003 |
Activin
system in the pituitary: how important is it in the differential
expression of fish FSH and LH? - $699,600
|
| 1999-2001 |
Transcriptional
regulation of gonadotropin-I and II (GTH-I and II) genes
in the goldfish by activin - functional analysis of cis-acting
elements that mediate activin stimulation of GTH-I and inhibition
of GTH-II in the goldfish, Carassius auratus - HK$789,000
|
| 1996-1998 |
Activin
regulation of pituitary gonadotropin gene expression and oocyte
development in the goldfish, Carassius auratus -
HK$865,000
|
Strategic Grant |
| 2000-2004 |
Strategies
for the improvement of marine fish and shrimp culture: a molecular
biological approach - HK$500,000 (co-investigator)
|
| |
|
| Awards |
| 2003 |
The
VC¡¦s Exemplary Teaching Award, The Chinese University
of Hong Kong
|
| 2003 |
Exemplary
Teaching Award, Faculty of Science, The Chinese University
of Hong Kong
|
| 2001 |
Exemplary
Teaching Award, Faculty of Science, The Chinese University
of Hong Kong |
| 1996 |
Biology
Society Best Lecturer Award, Department of Biology, The
Chinese University of Hong Kong. |
|
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